Browsing by Author "Rathnam, M.V."
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Item Interaction studies in binary liquid mixtures of methyl formate with o-, m- and p-xylenes using viscosity data at 303.15K(2012-01) Rathnam, M.V.; Mohite, Sudhir; Kumar, MSSDensities, viscosities, refractive indices of binary liquid mixtures composed of methyl formate and o-, m- and p-xylenes were determined at 303.15K and atmospheric pressure for he whole range of composition. From the experimental results the deviation in viscosity (), excess Gibbs free energy of activation of flow (DG*E), and the deviation in molar refraction (R) were deduced. The deviation in viscosities were correlated with Redlich-Kister polynomial equation. The values are negative while the values of DG*E are positive and the R values are both positive and negative over the entire range of composition for all the studied systems. The ability of different one parameter and two parameter empirical models to predict mixing viscosities was also studied.Item Simultaneous Rp Hplc Determination Of Camylofin Dihydrochloride And Paracetamol In Pharmaceutical Preparations.(2012-01) Singh, R.R.; Rathnam, M.V.; Vegesena, D.R.A simple, fast and precise reversed phase high performance liquid chromatographic method is developed for the simultaneous determination of camylofin dihydrochloride and paracetamole using methyl paraben as an internal standard. Chromatographic separation of these two drugs was performed on waters symmetry C18 column (250 mm x 4.6 mm, 5 mm) as stationary phase with a mobile phase comprising of 0.05% trifluoro acetic acid in water and 0.05% trifluoro acetic acid in acetonitrile (50 : 50 v/v), at a flow rate of 1.0 mL min-1 and UV detection at 220 nm. The Retention time of Camylofin dihydrochloride and paracetamol and Methyl paraben were 3.10 min, 3.42 min and 4.70 min respectively. The proposed method was validated for linearity, accuracy, precision, LOD, LOQ. Linearity, accuracy and precision were found to be acceptable over the ranges of 25-75 mg mL-1 for camylofin dihydrochloride and 250-750 - mg mL-1 for paracetamol. It can be conveniently adopted for routine quality control analysis.